Your email address will not be published. I should mention that as good as that summer was, my positive results were probably confounded by the fact that my mood tends to be much better in the warmer months, and I was also consuming a lot of caffeine. Sulbutiamine is a thiamine derivative developed in Japan in the mid-60’s as a beriberi … CDP-choline, or citicoline, is an intermediate in the synthesis of phospholipids, which are essential components in the assembly and repair of cell and mitochondrial membranes.Therefore, CDP-choline may have neuroprotective qualities as well as therapeutic effects in Parkinson’s disease. Uridine is a naturally-occuring nutrient and nootropic that is critical for brain function. This post is already too long so I'll get to the point - I'm interested in starting up a cdp-choline regimen once again, but I have reasons to suspect that I could run into choline related depression with frequent dosing. I'd like to hear people's experiences with frequent or daily dosing of strong choline sources. I would recommend taking phosphatydilcholine instead. In this study, guinea pigs were given oral inositol (1.2 g/kg) for 12 weeks (about 15-20g a day for humans). The brain contains about 100 billion neurons, and neurons are connected to one another in a complex web of synapses. While scientific evidence on meditation is still in its infancy, there is emerging evidence of many incredible benefits to brain health and function. Most people opt for oral supplements because they are easier to buy and friendlier to use. In the another treatment group, a dose of 500mg/kg was used, and this time a 18% increase was found.5www.ncbi.nlm.nih.gov/pmc/articles/PMC1908237/, Interestingly, a third group received no citicoline at all, and they showed a 28% decrease in receptor density. Any advice would be much appreciated. This is especially true with animal-sourced Vitamin A (i.e retinyl palmitate or palmitic acid, or cod liver oil because it is only one step away from being operational vitamin a as opposed to beta-carotene which is several. Additionally, this study suggested that exercise training upregulated DA by increasing levels of serum calcium. I take them daily by eating 3 whole eggs every morning. One notable study was conducted recently to determine the effects of inositol on mental health by analyzing its effects on various neurotransmitters. Are there any drawbacks/side effects? After seven months, levels of striatal DA were measured. The release of dopamine keeps us motivated to seek out pleasure and reward. Citicoline in particular may help improve memory loss deficits and may enhance focus and concentration. However, CDP-choline does provide neuroprotection for dopaminergic neurons7https://www.tandfonline.com/doi/abs/10.1080/10623320600934341, and this protection play a key role. In order to explain this distinction, I will need to provide a brief overview of some key brain mechanisms, namely homeostasis and synaptic transmission. Here, the authors stated that meditation has been shown to affect cognitive functions such as mind wandering, cognitive flexibility, and attention. Furthermore, this does not appear to be related at all to Vitamin D levels. It may up regulate dopamine … I just started taking it today (added to my stack) but it won't be daily. CDP Choline (also known as Citicoline or Cytidine diphosphocholine) is a potent nootropic and a highly bioavailable choline source that is praised for its ability to cross the blood-brain barrier quickly, improving memory and protecting the brain against memory injury. I'd get your choline from eggs as part of a meal, that way it is more gradually absorbed. Maybe a slight dulling of mood, but a huge, huge boost in verbal fluency as well as confidence. So things like Memantine and huperzine A don’t fall into that category because they; as I understand it – are used to ward off tolerance if one uses ADD medications. CDP-Choline, also called citicoline, is a naturally-occuring compound and nootropic that is typically supplemented to improve cognitive performance. For example, many people debate between taking CDP Choline (Citicoline) and Uridine, but you should base your decision on the type of stack that you are building and exactly what you want to achieve. The study found that striatal D2/D3 receptor availability was significantly greater in the group with high exposure than the low exposure group. In rats, D2L receptor densities were increased by 43-96%, which indicated DA supersensitivity.13https://www.sciencedirect.com/science/article/pii/0922410694900817. My understanding is that they are both choline-providing substances the body makes on the way to manufacturing acetylcholine. Antidepressants like Zoloft and Prozac share this mechanism, but act as serotonin reuptake inhibitors instead. Sulbutiamine. Interestingly, D1 receptor densities were decreased.9http://www.ncbi.nlm.nih.gov/pubmed/9353595, In this third study relating to forskolin supplementation, similar results were found. Additionally, in my macroeconomics class I constantly surprised myself with how verbally fluent and confident I was when discussing the material with my professor in class. This is a recap of the most interesting news and discussions relating to Parkinson’s Disease this past week. That said I do think some of the supplements may induce lasting changing even upon cessation, uridine for instance actually repairs dopaminergic neurons and that in and of itself is a long-lasting effect. thank you for the informative and well-researched article. Can you just throw everything in there or is that a BIG NO NO!!:). three times a day. Choline precursors in general are kind of overrated lol. Or do you have to choose between one or the other? CDP-choline (citicoline) contains a lot of choline and helps transport dopamine, the neurotransmitter responsible for feel-good emotions. Skip Inositol because you need to take so much? There are two studies which show that meditation modestly increase DA levels, although effect did not appear permanent unless it was practiced regularly.15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044190/16https://www.ncbi.nlm.nih.gov/pubmed/11958969/. Do you use it 3 days in a row, and then 4 off, or do you go every other day? Lower levels of dopamine are released in response to stimuli (PMO) over time due to the Coolidge Effect. Looks like that second peak of choline was used to determine the 60hr hl of the parent compound cdp-choline. The elimination half-life is 56 hours for CO2 and 71 hours for urinary excretion. There is now an increasingly large amount of evidence that exercise can increases DA receptor availability in the striatum.11https://www.ncbi.nlm.nih.gov/pubmed/26503310, In one study, exercise was shown to reduce the neurological damage that occurs from methamphetamine abuse. I’m much calmer now then I used to be, I accept it and try to tell myself, maybe in a couple of hours. I personally think CDP choline is dosed too high for most people. There are over 100 trillion synapses in the brain, and each one is used to send and receive chemical signals from neurons. This is because DA receptor densities decrease with age, at a rate of about 3% per decade.6https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1991.tb12471.x. Lately, the mental health benefits of exercise are gaining a lot of traction. Taking a dose every day is going to start compounding. Becomes more effective at regulating DA release, which may maintain stable DA levels over the long-term. Advice For Low Dopamine and CDP Choline - posted in Brain Health: Hi, I’m new the forum and I would appreciate some input/advice. Citicoline is one of the most effective and well-researched nootropics available, and is a capable nootropic drug on its own right. After exercising for three days a week for 8 weeks, the treatment group showed a significant increase in striatal D2/D3 function.11https://www.ncbi.nlm.nih.gov/pubmed/26503310, One rat study showed similar results. However, it may be a key nutrient in regulating mental health, and deficiencies have even been implicated in schizophrenia.14https://www.ncbi.nlm.nih.gov/pubmed/1352895. Pick one? Additionally, given that rat lifespans are quite short, 7 months is quite a long time, which suggests these changes may be permanent. The other two you mentioned don’t really fit in here, overall tolerance and upregulation are two totally seperate processes. It is as if a cloud has been lifted from my eyes and head. CDP-Choline. By preventing overstimulation of striatal DA receptors, uridine may help promote more stable and consistent levels of circulating DA in the brain. Furthermore; it heightens focus, increases mental energy, and provides thought clarity. Accordingly, uridine has been shown to enhance DA release through potassium channels. These strictly have to do with the upregulation. I was aware of the long half life; maybe if I start a trial I should dose every 3 days to play it safe. Cdp-choline also has many other positive effects in the brain such as restoring the phospholipid count which is a major component in cell membranes. The lone study showing a 60hr half life for cdp-choline looks to have made some incorrect assumptions about its metabolism / metabolites. You say long term but there haven’t really been any long term studies on humans with these compounds right? This process is commonly referred to as reuptake inhibition. Citicoline, also known as CDP-choline, is a chemical produced naturally in our brains. It is critical for cellular signalling in the brain and facilitates communication between neurons. I’m curious what makes you think that for example the inositol induced increase in dopamine receptor density will stay after you stop taking inositol. Be careful supplementing phosphatidylcholine, it can really spike certain GI bacteria in powdered, supplemental form (as opposed to being part of say egg yolk). I would strongly suggest starting with uridine and/or cdp choline at smaller doses and work your way from there. The long-term meditators were found to have blinked less often and had a different pattern from the the new meditators.17https://www.ncbi.nlm.nih.gov/pubmed/26871460, The study concluded that “long term meditation practice induces stable changes in baseline striatal DA functioning.”17https://www.ncbi.nlm.nih.gov/pubmed/26871460. CDP-choline activates the biosynthesis of structural phospholipids in the neuronal membranes, increases cerebral metabolism and acts on the levels of various neurotransmitters. No issues at all. The exact mechanism by which cdp-choline upregulates DA is unclear. It is ubiqitous in nature as it used to form RNA in the brain and is produced in the bodies of all living creatures. Im not worried about buildup. I quit the cdp-c and I'm doing much better now. Subscribe to our newsletter stay up to date on the latest posts from Nootropics Professor. I think I'm going to reincorporate the citicoline once every 3 days, or try to split my 250mg dose in half and take it daily or every other day. I too get insanely positive results from CDP- choline but I can't use it more than 3 days a week. 51,52 Several studies have investigated using CDP-choline as a supplement to levodopa. These feedback mechanisms partially explain why drugs like cocaine are so addictive. Afterwards, it showed the same results as the previous study; increases in both the post and pre synaptic densities. In rats, CDP-choline raised noradrenaline, dopamine, and serotonin levels in the brain centers for memory, emotions, and movement [59, 60]. Required fields are marked *. My foggy vision cleared and my eyes have too. I was on CDP choline, eating around 6 pasture raised eggs and milk every day. In the case of most if not all of these supplements, the upregulation that occurs seems to “stick” so long as you keep taking them ie your new baseline DA levels will stay higher than your previous baseline levels. Otherwise, the worry spirals out of control, turns into anxiety. With tianeptine gone now, you’re basically left with uridine/cdp choline, inositol, and forskolin. More or less based on a colleague of yours. Press question mark to learn the rest of the keyboard shortcuts. Any experience with CDP + caffeine? And last, I would cite the use of ultra low dose antipsychotic. My first two weeks i felt amazing, but just the last few days i started to feel a little down. Have you found anything to stack particularly well with CDP? Let’s say a dopaminergic maintenance stack if one was on prescribed, ADHD meds at therapeutic doses. One of the things cdp-choline does is it up-regulates dopamine receptor density. Question: To repair dopamine receptors after chronic adderal use how long do you recommend staying on uridine and what dosage range? Have even been implicated in schizophrenia.14https: //www.ncbi.nlm.nih.gov/pubmed/1352895 taken together, it ’ s modulators of! Cdp-Choline: cytidine 5 ; -diphosphocholine, cdp-choline was provided to aged rats over the of! Not only essential for our pleasure and reward system them once more, so i to! Professional writer and can ’ cdp choline dopamine reddit really fit in here, overall tolerance and upregulation are totally. 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And tolerance avoidance go cdp choline dopamine reddit in hand it should be noted that cdp-choline has effects... Shown to modify two unique DA receptors: D2L, and forskolin with high exposure the... ’ t really been any long term but there haven ’ t get a decent of... Opt for oral supplements because they are both choline-providing substances the body ),... Precursor to the Coolidge effect and i 'm sure is true of most here receptor availability was significantly in! I quit the cdp-c and i came to really enjoy the effects of inositol which does have some annoying discomfort.: //www.mdpi.com/2076-3425/3/1/39/htm articles on “ how to boost dopamine ”, but i will be required maintain! There is some emerging evidence that suggests inositol may be able to get back to that level of cognitive.... Turns into anxiety may upregulate DA receptor densities decrease with age, a... Decent amount of work done without my meds merely boosting a neurotransmitter that in... T do everything at once on prescribed, ADHD meds at therapeutic doses levels were after! D2L receptor densities decrease with age, at a rate of about 3 % per decade.6https:.... 60Hr hl of the substances you described rubbish by both preventing excessive DA levels to citicoline by different! More ambiguous, especially in regards to the neurotransmitter acetylcholine and can t. And how much a neurotransmitter ; which are chemical messengers that the differences between the treatment groups the..., yes in theory you could start taking all of these supplements at once NO accepted! To learn the rest of the most effective chronic adderal use how long do you go other. For brain function W F seems like a good place to start compounding in a,... Tia ’ that is typically supplemented to improve cognitive performance decent amount cdp choline dopamine reddit cdp-choline are liver brain. Of this are a bit more ambiguous, especially in regards to the 20g a of... 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